Effect of COVID-19 on Menstruation: An Observational Study





Humans, Female, Menstruation, Cross-Sectional Studies, COVID-19, Menstruation Disturbances, Menstrual Cycle, Surveys and Questionnaires, Probability


Introduction: COVID-19 patients have been reported to have systemic complications. Analyzing its effect on the endocrine

system is essential to ensure women’s reproductive health.

Aim: This study aimed to determine the effect of COVID-19 disease on menstruation.

Methods: It was a hospital-based cross-sectional study conducted from October 2021 to April 2022, using a validated questionnaire

to collect the data. The study included females (15 to 49 years) who had confirmed COVID infection.

Results: A total of 132 females participated in the study. For 29 (22%) patients presenting with menstrual cycle changes, most common change was prolonged cycle (14%). An increase in menstrual volume was reported by 12%, where as 35% of patients experienced more pain during menstruation. Menstrual irregularities were significantly higher in severe infection (p-value 0.04).

Conclusion: There were transient changes in menstruation in COVID-19-infected patients, with a higher probability of menstruation abnormalities among severely infected patients.


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Fu J, Zhou B, Zhang L, Balaji KS, Wei C, Liu X, Chen H, Peng J, Fu J. Expressions and significances of the angiotensin-converting enzyme 2 gene, the receptor of SARS-CoV-2 for COVID-19. Molecular biology reports. 2020 Jun;47:4383-92.

Thakur V, Ratho RK, Kumar P, Bhatia SK, Bora I, Mohi GK, Saxena SK, Devi M, Yadav D, Mehariya S. Multi-organ involvement in COVID-19: beyond pulmonary manifestations. Journal of clinical medicine. 2021 Jan 24;10(3):446.

Tang K, Gaoshan J, Ahonsi B, Ali M, Bonet M, Broutet N, Kara E, Kim C, Thorson A, Thwin SS. Sexual and reproductive health (SRH): a key issue in the emergency response to the coronavirus disease (COVID- 19) outbreak. Reproductive Health. 2020 Dec;17(1):1-3.

Li K, Chen G, Hou H, Liao Q, Chen J, Bai H, Lee S, Wang C, Li H, Cheng L, Ai J. Analysis of sex hormones and menstruation in COVID- 19 women of child-bearing age. Reproductive biomedicine online. 2021 Jan 1;42(1):260-7.

World Health Organization 2. Clinical management of COVID-19:interim guidance, 27 May 2020. World Health Organization; 2020.

Kurmanova AM, Kurmanova GM, Lokshin VN. Reproductive dysfunctions in viral hepatitis. Gynecological Endocrinology. 2016 Sep 30;32(sup2):37-40.

Yuksel B, Ozgor F. Effect of the COVID?19 pandemic on female sexual behavior. International Journal of Gynecology & Obstetrics. 2020 Jul;150(1):98-102.

Phelan N, Behan LA, Owens L. The impact of the COVID-19 pandemic on women’s reproductive health. Frontiers in endocrinology. 2021 Mar 22;12:642755.

Liu X, Yang Y, Yuan P, Zhang X, Han Y, Cao Y, Xiong G. A study of the relationship between mental health and menstrual abnormalities in female middle school students from post-earthquake Wenchuan. Bioscience trends. 2010 Feb 1;4(1).

Chrousos GP, Torpy DJ, Gold PW. Interactions between the hypothalamic-pituitary-adrenal axis and the female reproductive system: clinical implications. Annals of internal medicine. 1998 Aug 1;129(3):229-40.




How to Cite

Singh M, Kaur M, Verma A, Sharma N. Effect of COVID-19 on Menstruation: An Observational Study. Indian J Community Health [Internet]. 2023 Jun. 30 [cited 2024 Jul. 24];35(2):227-30. Available from: https://www.iapsmupuk.org/journal/index.php/IJCH/article/view/2530



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