Hyperacute Liver Failure with Multi-organ Dysfunction Syndrome (MODS) by Leptospirosis: A Case Report

Authors

  • Nilay Tripathi Vivekananda Polyclinic and Institute of Medical Sciences, Ramakrishna Mission Sevashrama, Lucknow, India
  • Naresh Rajpal Vivekananda Polyclinic and Institute of Medical Sciences, Ramakrishna Mission Sevashrama, Lucknow, India
  • Gaurav Jain Vivekananda Polyclinic and Institute of Medical Sciences, Ramakrishna Mission Sevashrama, Lucknow, India
  • Prashant Katiyar

DOI:

https://doi.org/10.47203/IJCH.2023.v35i02.020

Keywords:

leptospirosis, Acute fulminant hepatic failure, Multi organ dysfunction syndrome

Abstract

Introduction: Leptospirosis may have multi-organ involvement in its severe form with potentially life-threatening consequences. However, acute fulminant hepatic failure is very uncommonly reported. A case study is presented here with fulminant hepatic failure and a diagnostic dilemma for etiology.
Case history: A 40-year-old man with no significant medical history presented with fever, muscle pain, weakness, and pain in the upper abdomen. On clinical work, he has developed multi-organ hepatic, respiratory, and renal failure. A timely workup was done, but due to the rapid progression of the disease, the patient succumbed to the disease in the intensive care unit by the time his report for positive leptospirosis test arrived.
Conclusion: Leptospirosis must be considered as an important differential diagnosis of acute liver failure patients. An early suspicion for leptospirosis in patients with fulminant hepatic failure and multi-organ failure in India particularly in the rainy season is warranted owing to its high mortality rate.

Downloads

Download data is not yet available.

References

Levett PN. Leptospirosis. Clin Microbiol Rev. 2001 Apr;14(2):296-326. doi: 10.1128/CMR.14.2.296-326.2001. PMID: 11292640; PMCID: PMC88975.

Dutta TK, Christopher M. Leptospirosis--an overview. J Assoc Physicians India. 2005 Jun;53:545-51. PMID: 16121811.

Sambasiva RR, Naveen G, P B, Agarwal SK. Leptospirosis in India and the rest of the world. Braz J Infect Dis. 2003 Jun;7(3):178-93. doi: 10.1590/s1413-86702003000300003. PMID: 14499041.

Izurieta R, Galwankar S, Clem A. Leptospirosis: The “mysterious” mimic. J Emerg Trauma Shock. 2008 Jan;1(1):21- 33. doi: 10.4103/0974-2700.40573. PMID: 19561939; PMCID: PMC2700559.

Vijayachari P, Sugunan AP, Shriram AN. Leptospirosis: an emerging global public health problem. J Biosci. 2008 Nov;33(4):557-69. doi: 10.1007/s12038-008-0074-z. PMID: 19208981.

Sehgal SC. Leptospirosis on the horizon. Natl Med J India. 2000 Sep-Oct;13(5):228-30. PMID: 11190049.

Sethi S, Sharma N, Kakkar N, Taneja J, Chatterjee SS, Banga SS, Sharma M. Increasing trends of leptospirosis in northern India: a clinico-epidemiological study. PLoS Negl Trop Dis. 2010 Jan 12;4(1):e579. doi: 10.1371/journal.pntd.0000579. PMID: 20084097; PMCID: PMC2797087.

Manocha H, Ghoshal U, Singh SK, Kishore J, Ayyagari A. Frequency of leptospirosis in patients of acute febrile illness in Uttar Pradesh. J Assoc Physicians India. 2004 Aug;52:623- 5. PMID: 15847355.

Gupta N, Rao RS, Bhalla P, Agarwal SK. Seroprevalence of leptospirosis in Delhi using indirect haemagglutination assay. Indian J Med Microbiol. 2004 Apr-Jun;22(2):134-5. PMID: 17642716.

Sethi S, Sood A, Pooja, Sharma S, Sengupta C, Sharma M. Leptospirosis in northern India: a clinical and serological study. Southeast Asian J Trop Med Public Health. 2003 Dec;34(4):822-5. PMID: 15115094.

Chaudhry R, Premlatha MM, Mohanty S, Dhawan B, Singh KK, Dey AB. Emerging leptospirosis, North India. Emerg Infect Dis. 2002 Dec;8(12):1526-7. doi: 10.3201/eid0812.020052. PMID: 12498680; PMCID: PMC2738520.

Kaur IR, Sachdeva R, Arora V, Talwar V. Preliminary survey of leptospirosis amongst febrile patients from urban slums of East Delhi. J Assoc Physicians India. 2003 Mar;51:249-51. PMID: 12839344.

Chauhan V, Mahesh DM, Panda P, Mokta J, Thakur S. Profile of patients of leptospirosis in sub-Himalayan region of North

India. J Assoc Physicians India. 2010 Jun;58:354-6. PMID: 21125775.

Goswami RP, Goswami RP, Basu A, Tripathi SK, Chakrabarti S, Chattopadhyay I. Predictors of mortality in leptospirosis: an observational study from two hospitals in Kolkata, eastern India. Trans R Soc Trop Med Hyg. 2014 Dec;108(12):791-6. doi: 10.1093/trstmh/tru144. Epub 2014 Oct 30. PMID: 25359

Downloads

Published

2023-06-30

How to Cite

1.
Tripathi N, Rajpal N, Jain G, Katiyar P. Hyperacute Liver Failure with Multi-organ Dysfunction Syndrome (MODS) by Leptospirosis: A Case Report. Indian J Community Health [Internet]. 2023 Jun. 30 [cited 2024 Jul. 24];35(2):243-5. Available from: https://www.iapsmupuk.org/journal/index.php/IJCH/article/view/2637

Issue

Section

Short Article

Most read articles by the same author(s)