Comparative Burden of HbA1c and RBG Levels Among Individuals Above 25 Years in the Post-COVID-19 and Pre-COVID-19 Periods: A Retrospective Analysis at a Medical College Hospital, Ramanagara, Karnataka
Impact of COVID on RBG levels
DOI:
https://doi.org/10.47203/IJCH.2025.v37i04.012Keywords:
Hyperglycemia, HBAIc, RBG, COVIDAbstract
Introduction
The COVID-19 pandemic significantly impacted public health, including metabolic health and glycemic control. SARS-CoV-2 affects glucose metabolism through inflammation, stress, and healthcare disruptions. HbA1c, a key diabetes marker, has shown increased levels post-COVID, suggesting higher hyperglycemia burden. In India, pre-COVID data revealed 12% of women and 14% of men over 15 years had RBG >140 mg/dl, with higher rates reported during COVID due to stress, inflammation, and treatment changes like corticosteroid use. We hypothesized a 15% rise in elevated HbA1c and RBG levels post-COVID among patients over 25 years. This study compared pre- and post-COVID trends by age and gender.
Methods:
The study was conducted at CDSIMER Hospital, as a retrospective observational analysis of HbA1c and RBG levels in patients aged >25 years. Two periods were compared: Pre-COVID-19 (2019–2021) and Post-COVID-19 (2022–2023). Data from the Laboratory Information System (LIS) and NFHS-5 reports were analyzed. Inclusion criteria included complete HbA1c and RBG records. The estimated sample size, based on previous studies, was 10,475.
Results:
A total of 17,238 patients data were analysed. In the post-COVID period, 16.95% had very high levels (?160 mg%), more than doubling from NFHS-5 data. Males showed a higher prevalence (22.15%) than females (12.86%). HbA1c >6.5% was found in 64% of individuals aged >25 years.
Conclusion:
Alarming increase in blood glucose levels among population aged above 25 years. National Health Programmes to take justifiable action on priority.
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References
Apicella M, Campopiano MC, Mantuano M, Mazoni L, Coppelli A, Del Prato S. COVID-19 in people with diabetes: understanding the reasons for worse outcomes. Lancet Diabetes Endocrinol. 2020;8(9):782-92.
Montefusco L, Ben Nasr M, D’Addio F, Loretelli C, Rossi A, Pastore I, et al. Acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection. Nat Metab. 2021;3(6):774-85.
Rubino F, Amiel SA, Zimmet P, Alberti G, Bornstein S, Eckel RH, et al. New-onset diabetes in COVID-19. N Engl J Med. 2020;383(8):789-90.
International Institute for Population Sciences (IIPS), ICF. National Family Health Survey (NFHS-4), 2015–16: India.Mumbai: IIPS; 2017. Available from: https://dhsprogram.com/publications/publication-fr339-dhs-final-reports.cfm (accessed on 25 Aug 25)
Unnikrishnan R, Misra A, Yadav R. COVID-19 and diabetes: Risks, mechanisms and management strategies. Diabetes Metab Syndr. 2021;15(4):102176.
Montefusco L, Ben Nasr M, D’Addio F, et al. Acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection. Nat Metab. 2021;3(6):774-85.
Sathish T, Cao Y. Is new-onset diabetes after COVID-19 part of post-COVID-19 syndrome? Diabetes Metab Syndr.2021;15(4):102-4.
Cummings JL, Morstatter F, Vyas A. The impact of the COVID-19 pandemic on dietary habits and physical activity in India. J Public Health Res. 2022;11(2):230-5.
Lim S, Bae JH, Kwon HS, Nauck MA. COVID-19 and diabetes mellitus: from pathophysiology to clinical management. Nat Rev Endocrinol. 2021;17(1):11-30.
Klein S, Flanagan KL. Sex differences in immune responses. Nat Rev Immunol. 2016;16(10):626-38.
Ding T, Zhang J, Wang T, et al. Gender differences in metabolic syndrome and its components among Chinese adults: a longitudinal study. BMC Public Health. 2021;21(1):31.
Gupta R, Gaur K, Sahoo AK. Urban-rural disparities in diabetes prevalence and risk factors in India: a systematic review. J Diabetes Res. 2022;2022:1-12.
Anjana RM, Deepa M, Pradeepa R, et al. Prevalence of diabetes and prediabetes in urban and rural India: Phase I results of the Indian Council of Medical Research–INdia DIABetes (ICMR–INDIAB) study. Diabetologia.2011;54(12):3022-7.
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