A retrospective cohort study to find out the association of hydroxychloroquine prophylaxis and COVID 19 infection prevention among health care workers in a tertiary care hospital of New Delhi
DOI:
https://doi.org/10.47203/IJCH.2021.v33i02.005Keywords:
Hydroxychloroquine Prophylaxis, Covid-19 Infection, Health Care Workers, Retrospective Cohort StudyAbstract
Background- With the high morbidity and mortality year 2020 will be remembered as Covid19 pandemic year. Occupational exposure to COVID 19 among health care workers poses a major risk to their lives. Hydroxychloroquine (HCQ) prophylaxis has been indicated for their use without much scientific evidence. Objective- to find if HCQ prophylaxis had association with Covid19 infection prevention among health care workers. Material &Method- A retrospective cohort study was conducted; through online by utilizing social media platform, among Health care workers of a tertiary care hospital from 1st June 2020 to 27 July 2020. Those HCWs who have taken HCQ (exposed) and who have not taken (nonexposed) and PCR tested Covid19 Positive were taken as diseased. Results Out of 527 who were analyzed, study subjects who took HCQ prophylaxis had 30% less chance of having Covid19 test positive, {RR- 0.709(0.383-1.296)} as compared those who didn’t took it, but the results were not significant. Conclusion- Hydroxychloroquine prophylaxis does not prevent Covid 19 infection and more evidence may be required for use of HCQ prophylaxis for Covid19 infection.
Keywords- Hydroxychloroquine prophylaxis, Covid19 infection, Health care workers, Retrospective cohort study
Downloads
References
Martini M, Gazzaniga V, Bragazzi NL, Barberis I. The Spanish Influenza Pandemic: a lesson from history 100 years after 1918. J Prev Med Hyg. 2019;60(1):E64?E67. Published 2019 Mar 29. doi:10.15167/2421-4248/jpmh2019.60.1.1205
Coronavirus disease (COVID-19) Situation Report – 113 Data as received by WHO from national authorities, 27 Aug 2020 [cited on 28 Aug 2020] Available from: https://www.who.int/docs/default-source/coronaviruse/situation-reports/2020809-covid-19-sitrep-202.pdf?sfvrsn=feac3b6d_2
Liu Y, Gayle AA, Wilder-Smith A, Rocklöv J. The reproductive number of COVID-19 is higher compared to SARS corona virus. J Travel Med. 2020; 27(2):taaa021.
Ingraham NE, Boulware D, Sparks MA, et al. Shining a light on the evidence for hydroxychloroquine in SARS-CoV-2. Crit Care. 2020; 24(1):182.
National Taskforce for COVID-19. Advisory on the use of hydroxy-chloroquine as prophylaxis for SARS-CoV-2 infection. 2020. https://www.mohfw.gov.in/pdf/AdvisoryontheuseofHydroxychloroquinasprophylaxisforSARSCoV2infection.pdf(accessed on 25.06.2021).
Revised advisory on the use of Hydroxychloroquine (HCQ) as prophylaxis for COVID-19 infection (in supersession of previous advisory dated 23rd March, 2020). https://www.mohfw.gov.in/pdf/RevisedAdvisoryontheuseofHydroxychloroquinasprophylaxisforSARSCoV2infection. (accessed on Jun 25, 2021).
TahiriJouteiHassani R, Bennis A. Hydroxychloroquine as antiviral prophylaxis for exposed caregivers to Covid-19: An urgent appraisal is needed. J Infect Public Health. 2020;13(6):865-867. doi:10.1016/j.jiph.2020.05.005
Yao X, Ye F, Zhang M, et al. In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome Coronavirus 2 (SARS- CoV-2). Clin Infect Dis. 2020:ciaa237.
Liu J, Cao R, Xu M, et al. Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro. Cell Discov. 2020; 6:1-4.
Wang M, Cao R, Zhang L, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020; 30:269-271.
Boulware DR, Pullen MF, Bangdiwala AS, et al. A Randomized Trial of Hydroxychloroquine as Post exposure Prophylaxis for Covid-19 [published online ahead of print, 2020 Jun 3]. N Engl J Med. 2020; NEJMoa2016638. doi:10.1056/NEJMoa201663
Sun HeeLee,HyunjinSon, Kyong Ran Peck. Can post-exposure prophylaxis for COVID-19 be considered as one of outbreak response strategies in long-term care hospitals? International Journal of Antimicrobial Agents (2020), doi: https://doi.org/10.1016/j.ijantimicag.2020.105988
Chatterjee et al: HCQ prophylaxis in HCW in India. Indian J Med Res 2020, Epub ahead of print DOI: 10.4103/ijmr.IJMR_2234_20
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Indian Journal of Community Health
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
